Posts Tagged ‘tesofensine’

Wanna Lose Weight?…Here Comes Big Pharma's Newest and Bestest Magic Bullet

October 23rd, 2008

Back in May of this year, I told you about Tesofensine, a new diet drug being developed by the Danish drug company, NeuroSearch.

Well, it’s back in the news.

A new study, published in the online version of the Lancet, is singing the praises of Big Pharma’s latest attempt at weight loss in a pill.

Following up on their initial tests, this latest study claims that “Tesofensine produces a weight loss of approximately 10 percent more than placebo and diet in obese patients,” said lead researcher Dr. Arne Astrup, from the Department of Human Nutrition, Faculty of Life Sciences, at the University of Copenhagen.

Other drugs produce only about 5 percent weight loss, Astrup noted.

The researchers seem to be pretty excited about tesofensine’s ability to compete head to head with gastric bypass surgery for the title of medical weight loss champion.

According to the researchers, “This drug could replace the need for gastric bypass surgery in some obese patients”.

“There is an enormous gap between the existing weight-loss compounds and gastric surgery,” Astrup said. “Tesofensine could close that gap.

“If you combine the drug with an effective diet, you could probably reach the 20 percent weight loss seen in gastric surgery.”

This is my favorite part of the quote:

“Tesofensine could compete with gastric surgery and be offered to those who are below the threshold for surgery or for patients who do not wish [to have] gastric surgery,” Astrup said.

“There are also patients who cannot tolerate gastric surgery.”

So let me get this straight.

Finally, there is a solution for all of those poor unfortunate overweight individuals who happen to be below the threshold for gastric surgery, cannot tolerate surgery or foolishly do not wish to have gastric surgery.

And that solution is:

Tesofensine

Perhaps there is another solution.

How about a little less of this:

And a little more of this:

Instead of:

Relying on a pharmaceutical solution which:

  • Alters levels of three key brain chemicals – serotonin, dopamine and noradrenaline

Professor Steve O’Rahilly, a Cambridge University obesity expert, said: ‘If we could treat obesity, like we treat high blood pressure, with safe, effective and affordable drugs this would be an enormous boon to health care.

‘To date, obesity drugs that have been effective have not been safe, and conversely those that are safer, are relatively ineffective. The results with this new drug demonstrate that, over a six-month period, it is quite effective.

However, as the drug is likely to have actions on parts of the brain not involved in weight control, the risk of serious side effects on longer-term administration will need to be watched very carefully.’

  • Stops working as soon as you stop taking it.

Once starting the drug, people would need to keep taking it to maintain the benefit, Astrup said. “There is no treatment that is working beyond its taking. This is true for all anti-diabetic medication, hypertension medication and everything, including anti-obesity drugs,” he said. “It’s a long-term treatment, and, in some cases, a permanent treatment to keep body weight down.

  • And has numerous short-term side effects:
  • Nausea
  • Diarrhea
  • Constipation
  • Insomnia
  • Mood changes, such as anger and confusion
  • Increased Heart Rate
  • Increased Blood Pressure

The choice is yours.

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New Diet Drug offers an Alternative to Obesity Surgery

May 27th, 2008

Tesofensine, a new diet drug being developed by the Danish drug company, NeuroSearch, had it’s coming out party at this years European Congress on Obesity.

Recent tests claimed that, with no changes to diet or lifestyle, the average test subject experienced an 11.2% average reduction in weight. In absolute terms, the average test subject lost 11.3 kg / 24.9 lbs. This weight loss took place over the course of a 24 week treatment with 0.5 mg Tesofensine tablets.

More data here.

TIPO-1 results
Placebo
Tesofensine
0.25 mg
Tesofensine
0.5 mg
Tesofensine
1.0 mg
ITT* population
52
52
50
49
Mean weight
at base line (kg)
103.2
101.7
100.1
101.3
Average relative
weight loss
2.0%
6.5%**
11.2%**
12.6%**
Average absolute
weight loss (kg)
2.2
6.7**
11.3**
12.8**

25 lbs over 6 months with no additional exercise or dietary restriction.

Sounds pretty great.

In another test, Tesofensine produced 2.2 kg/4.85 lbs of weight loss in just 2 weeks. Once again, this test required that no dietary or lifestyle changes be made by the participants.

Tesofensine
Placebo
Population (ITT)
n = 16
n = 16
Baseline average BMI
30.7
31.1
Baseline average weight (kg)
102.6
102.6
Total body weight loss (kg)
2.2
0.4
Maximum weight loss (kg)
4.7
1.5

Professor Arne Astrup, president of the International Association for the Study of Obesity said that “if doctors were to encourage users to lose weight before taking the tablets and to eat sensibly and exercise while taking them they could double their weight loss”.

“You could easily come up to 20 per cent weight loss which could offer an alternative to the surgical treatment of obesity which has become the only real cure or effective treatment that can provide a weight loss of that size”.

While I don’t agree with Dr. Astrup’s assertion that bariatric surgery is the only real cure or effective treatment for obesity, I am encouraged by the efficacy of this drug.

The Down Side

Not to be pessimistic, but how many times in the past have drug manufacturers claimed to have formulated the ultimate fat burning pill? Does anyone remember fen-Phen?

Right now, we know that there have been some promising tests. We also know that the drug has the following side effects: mild nausea, diarrhea, constipation, insomnia, mood changes, and, perhaps most importantly, increased heart rate.

My Conclusion

Unless you have a very serious medical condition that requires you to lose weight as soon as possible, I would not recommend being an ‘early adopter’ of any diet drug. NeuroSearch will be running further tests to look at increasing the efficacy and minimizing the side effects.

In the mean time, improving your physical fitness and your food intake is still the best way to go.

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