Posts Tagged ‘pancreas’

Obesity = Inflammation = Cancer

January 22nd, 2010

Every January 1st, millions of people resolve to get in shape and lose weight.

Unfortunately, before February 1st rolls around, two thirds of those people have fallen off the bandwagon, abandoned their gym memberships and returned to the normal diet of pizza & ice cream.

So, in an attempt to recharge your collective weight-loss motivation, I thought I would let you in on a recent piece of obesity research that concluded that…

Obesity = Inflammation = Cancer

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Yep, cancer…the big C.

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According to this latest research, obesity enhances the development of a form of liver cancer called HCC (hepatocellular carcinoma) by:

  1. Stimulating the production of tumor-promoting cytokines (interleukin-6 {Il-6} and tumor necrosis factor {tnf})
  2. Il-6 and tnf causes inflammation in your liver, and
  3. Activates a tumor-producing transcription factor called STAT3
  4. STAT3 activates the formation and growth of the HCC liver cancer

Or, in layman’s terms

Obesity = Inflammation = Cancer

But, it’s not just liver cancer.

Obesity also increases the risk of developing pancreatic, GI and kidney cancers.

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So, how about that slice of pizza?

Feeling hungry?

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PEDF: The link between Obesity and Type 2 Diabetes?

July 8th, 2009

Stereoscopic model of pigment epithelium-derived factor derived from the crystal structure

Stereoscopic model of PEDF

Link between obesity and diabetes discovered

Researchers at Monash University (led by Associate Professor Matthew Watt), have discovered that fat cells release a novel protein called PEDF (pigment epithelium-derived factor), which triggers a chain of events and interactions that lead to development of Type 2 diabetes.

According to Dr. Watt:

  • When PEDF is released into the bloodstream, it causes the muscle and liver to become desensitized to insulin. The pancreas then produces more insulin to counteract these negative effects
  • This insulin release causes the pancreas to become overworked, eventually slowing or stopping insulin release from the pancreas, leading to Type 2 diabetes.
  • It appears that the more fat tissue a person has the less sensitive they become to insulin. Therefore a greater amount of insulin is required to maintain the body’s regulation of blood-glucose.

Our research was able to show that increasing PEDF not only causes Type 2 diabetes like complications but that blocking PEDF reverses these effects.

In fact, after blocking the secretion of PEDF in test subjects, the body was able to return to being insulin-sensitive and therefore did not need excess insulin to remain regulated.

This research may be a significant breakthrough in explaining the reasons why obesity triggers the onset of Type 2 Diabetes.

Until now scientists knew there was a very clear pattern and had strong suspicions that a link existed between the two conditions, but our understanding of the chain of events that are caused by the release of PEDF shows a causal link, Dr. Watt said.

Type 2 diabetes patients will benefit knowing the two conditions are linked.

We already know that weight-loss generally improves the management of blood glucose levels in diabetes patients.

Researchers can now move forward knowing this link exists and can begin to design new drugs to improve the treatment of Type 2 diabetes….

pedf lifestyle

…or perhaps, instead of looking for a cure for this completely preventable lifestyle disease, we could throw some cash at health promotion and/or disease prevention.

fit lifestyle equation

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Why Do I Crave Carbs?

November 13th, 2008
chocoholic

Must...Eat...Chocolate

Why do I crave carbs?

Why does the smell of baking bread or chocolate cake or cookies or  hot chocolate or popcorn or…well, you get the idea…why does that stuff make me so hungry?

Why don’t I crave broccoli or tuna fish or butter?

Why am I such a slave to sugar?

Insulin, my friends, insulin.

And here’s why.

The Science behind Insulin and our Addiction to Carbs

Insulin is secreted by the pancreas.

It’s job is to take glucose from your blood, store it in your liver and muscles as glycogen and stop the use of body-fat for fuel.

It’s your storage hormone.

This you may know.

You probably also know that the glucose in your blood comes from eating carbohydrates.

Carbs = Sugar.

What you may don’t know is that insulin isn’t being secreted all the time. It is produced in waves or pulses.

In Fact:

  • The first insulin pulse comes just seconds after you eat carbs
  • This insulin pulse occurs before the sugar in the food even reaches your bloodstream
  • This burst of insulin lasts for 20 minutes before dying down
  • As the first insulin pulse fades away, a second, more gradual injection of insulin is released by the pancreas
  • This pulse lasts for several hours

So what does this all mean?

This means that:

  • The first insulin pulse is designed to prime your body for what is about to happen.
  • Your mind tells your pancreas that sugar is about to be released into the bloodstream and that it had better get ready
  • Ergo, it starts squirting out the insulin

Why does the pancreas need advance notice?

It takes 20 minutes for insulin to have any significant effect on blood-sugar.

Without the advance notice, and the pancreas’ early warning system, a heavy carb meal could result in symptoms of hyperglycemia:

  • A feeling of nervousness or jitteriness
  • A racing heart and pulse
  • Sweaty palms
  • And also a headache

So, is this is a good thing?

Yes and no.

Here’s the bad news.

This first wave of insulin secretion has also been described as increasing the “metabolic background of hunger.” As the insulin grabs hold of the blood-sugar and stores it away for later use, it also shuts down the release of body-fat as fuel.

Temporarily, this leaves your body starved for nutrients. You can’t use the energy from the meal or the fat from your love handles. Ooops.

As a result of this, you get hungry!

As a result of this, that meal starts to look better and taste better. And that’s why you keep making trips to the buffet. Your body is searching for energy. More importantly, it’s fuel of choice is sugar…fast absorbing sugar.

After some time, your metabolic system does balance out, and nutrients are released to be used as fuel and your hunger decreases.

So What Does This Have To Do With My Carb Addiction?

  1. Our diet is based on carbs – wheat, corn, rice, sugar
  2. When we eat meals based on carbs, our insulin spikes
  3. When we eat meals based on carbs, our appetite increases
  4. When we eat meals based on carbs, food (carbs in particular) tastes better
  5. When we eat meals based on carbs, we overeat trying to fuels our cells
  6. As a result, when we eat meals based on carbs, we force our bodies to crave carbs

And this is a best case scenario.

I am not even going to discuss how this pattern of overeating carbs can and does lead to Type 2 Diabetes.

I will save that discussion for antoher day.

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